As an immunologist and infectious disease specialist, I focus on basic investigations of host-pathogen interactions. I have a long-standing interest in immune response to infections. My laboratory focuses on the innate immune responses to clinically relevant fungal pathogens. We employ both cell biological and biochemical tools to understand the molecular mechanisms that govern host immunity to these microorganisms. Using mouse models with defined defects in innate immunity, we have described key mechanisms that orchestrate this immune response to fungal infections.